Born in 1754 in Florence and died in the same city in 1814. Studied art and specialized in bronze sculpture, painting on glass and copper engraving.

In 1773, he became an apprentice modeller in the wax modelling workshop of the Florentine Museo della Specola (Observatory Museum) under the direction of Abbot Fontana. Susini took the technique of wax modelling to the highest peak of artistic perfection achieved to that date. Many of Susini's wax anatomical models are kept at the universities of Pavia, Padua, Pisa, Bologna, Siena, Perugia and Cagliari.

The wax models on view in Cagliari are considered the finest of Susini's works because they represent his mature output. Other wax anatomical models are kept in Spain, England, Sweden, Russia and Austria. In Austria, hundreds of wax models are kept in the "Josephinum" palace in Vienna (the former Military Medical School). A number of Susini's wax models, particularly those depicting religious subjects, are exhibited in the Sanluri castle museum in the province of Cagliari.