Pibiri Monica

Ricercatore Confermato

Dip. Tossicologia-sez. di Oncologia e Patologia Molecolare

Indirizzo: Via Porcell n° 4

telefono: 070-6758637

ATTIVITA'  DIDATTICA   

­Patologia Generale (CdL Ostetricia)

Patologia Generale (CdL Tecniche della prevenzione nell’ambiente e nei luoghi di lavoro)

ATTIVITA' DI RICERCA

Analisi dei processi di morte cellulare in modelli sperimentali in vitro e in vivo

Studio dei processi di cancerogenesi  in modelli sperimentali in vivo

ELENCO DELLE 10 PUBBLICAZIONI CARATTERIZZANTI 

1. Perra A, Kowalik MA, Pibiri M, Ledda-Columbano GM, Columbano A.Thyroid hormone receptor ligands induce regression of rat preneoplastic liver  lesions causing their reversion to a differentiated phenotype. Hepatology. Apr;49(4):1287-96, 2009

2. Columbano A, Simbula M, Pibiri M, Perra A, Pisanu A, Uccheddu A, Ledda-Columbano GM. Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation. Lab Investigation, Apr; 88(4):408-15,2008

3. Columbano A, Simbula M, Pibiri M, Perra A, Deidda M, Locker J, Pisanu A, Uccheddu A, Ledda-Columbano GM. Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration. Cell Proliferation, Jun;41(3):521-31, 2008. 

4. Perra A, Pibiri M, Sulas P, Simbula G, Ledda-Columbano GM, Columbano A. Alpha-lipoic acid promotes the growth of rat hepatic preneoplastic lesions                  in the coline-deficient model. Carcinogenesis, Jan;29(1):161-8, 2007. 

5. Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, Pibiri M. Increased ROS generation and p53 activation in alpha-lipoic   acid-induced apoptosis of hepatoma cells. Apoptosis, Jan;12(1):113-23, 2007

6. A Columbano, M Pibiri, M Deidda, C Cossu, TS Scanlan, G Chiellini, S Muntoni, GM Ledda-Columbano. The thyroid hormone receptor-b agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 (7): 3211-3218, 2006

7. G.M. Ledda-Columbano, F. Molotzu, M. Pibiri, C. Cossu, A. Perra and A. Columbano. Thyroid hormone induces cyclin D1 nuclear traslocation and        DNA synthesis in adult rat cardiomyocites. FASEB J. ,20, 87-94, 2006

8. A Columbano, G.M. Ledda-Columbano, M. Pibiri, C. Cossu, M. Menagazzi, D.D. Moore, W. Huang, J. Tian and J. Locker. GADD45β is induced  through a CAR-dependent TNF-independent pathway in murine liver hyperplasia. Hepatology, 42, 1118-1126, 2005  

9. Ledda-Columbano GM, Pibiri M, Molotzu F, Cossu C, Sanna L, Simbula G, Perra A, Columbano A. Induction of hepatocyte proliferation by retinoic  acid Carcinogenesis, 25 (11): 2061-6, Nov 2004

10. Ledda-Columbano G. M., Pibiri M., Cossu C., Molotzu F., Locker J., Columbano A. Aging does not reduce the hepatocyte proliferative response of   mice to the primary mitogen TCPOBOP. Hepatology, 40 (4): 981-8, Oct 2004